Press: Trophogen Inc. Improving Human and Animal Health With Protein Engineering.

Improving Human and Animal Health With Protein Engineering.


Press Releases

Trophogen, Inc. Awarded $756,000 for Second Year of Phase 2 NIH/NCI Fast Track SBIR Grant for Development of Novel Human VEGF Analogs for Targeted Imaging of Undifferentiated Thyroid Cancer.
ROCKVILLE, MD, July 7th, 2015

Trophogen, Inc. Announces Signing of Exclusive Global Veterinary License and Purchase Agreement With Zoetis, Inc. for Recombinant Long- Acting and Superactive Bovine Follicle- Stimulating Hormone (rbFSH) Analog for Superovulation in Cows.
ROCKVILLE, MD, June 2nd, 2015

Trophogen Inc. and Bioniche Life Sciences Inc. terminated exclusive global veterinary license agreement effective immediately.
ROCKVILLE, MD, January 30, 2013

Bioniche Presents Preliminary Data on the Use of In-Licensed Superagonist Hormone Technology in Cattle. Data presented at the International Congress on Animal Reproduction in Vancouver, B.C.
BELLEVILLE, ON, July 31, 2012

Trophogen Selects ABL as Contract Manufacturer for Recombinant, Human Follicle-Stimulating Hormone (rhFSH) Analog.
ROCKVILLE, MD, January 10, 2012

Bioniche & Trophogen Sign Exclusive Global Veterinary License Agreement for Superagonist Hormone Technology Platform

Newspaper articles

Banking on a Big Biobetters Bonanza: Will China Use its Capabilities to Create Improved Biologics?
CPB Review., 2012

Trophogen wants to score $10M, development deals..
Washington Business Journal., March 23, 2007

The importance of sharing.
Baltimore Business Journal., April 24, 2006

Events & Networking.
The Business Gazette., February 2006

Adventure With Ventures.
The Scientist, February 2006

Biotech Quandary.
The Gazette, February 2005

Breaking with academia a tough choice for scientists.
The Daily Record, March 2002

Local biotech pulls NIH license away from giant pharma.
Washington Business Journal,, March 2002

Selected Publications

(99m)Tc-labeled-rhTSH analogue (TR1401) for imaging poorly differentiated metastatic thyroid cancer.
Thyroid., Vol.24(8), 2014.

Thyrotropic activity of recombinant human glycoprotein hormone analogs and pituitary mammalian gonadotropins in goldfish (Carassius auratus): insights into the evolution of thyrotropin receptor specificity.
Gen Comp Endocrinol, Vol.177(1), 2012.

Identification of novel TSH interaction sites by systematic binding analysis of the TSHR hinge region.
Endocrinology, Vol.152(8), 2011.

Effects of recombinant human thyroid-stimulating hormone superagonists on thyroidal uptake of 18F-fluorodeoxyglucose and radioiodide.
Thyroid, Vol.21(7), 2011.

Induction of increased FDG uptake and loss of sodium-iodide symporter expression by VEGFR-2 inhibitor in FRTL-5 cells: An in vitro flip-flop mechanizm.
Nuklear Medizin, Leipzig Vol.54, 2010.

Regulation of uptake of 18F-FDG by a follicular human thyroid cancer cell line with mutation-activated K-ras.
J Nucl Med, Vol.50(8), 2009.

Opportunities for the production of reccombinant gonadotropins for assisted reproduction and emnbryo transfer.
Canadian and American Embryo Transfer Association Joint Convention Proceedings, 59-67, 2009.

The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor.
J Biol Chem, Vol.284(24), 2009.

Challenges and opportunities of trapping ligands.
Mol Pharmacol, Vol.72(2), 2007.

Thyroid-Stimulating Hormone and Thyroid-Stimulating Hormone Receptor Structure-Function Relationships.
Physiol Rev, Vol.82, 2002.

Bioengineering of Human Thyrotropin Superactive Analogs by Site-directed “Lysine-scanning” Mutagenesis
JBC, Vol.275, 2000.

A rational design strategy for protein hormone superagonists.
Nature Biotechnology,Vol 16, September 1998.

Novel Insights into the Molecular Mechanisms of Human Thyrotropin Action: Structural, Physiological, and Therapeutic Implications for the Glycoprotein Hormone Family.
Endocrine Reviews, Vol.18, August 1997.

Engineering human glycoprotein hormone superactive analogues.
Nature Biotechnology, Vol.14, October 1996.


Trophogen Inc. 2015